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Scientist IV, AAV - Computer-aided Biology

Date: 21-Nov-2021

Location: Oxford, GB

Company: oxfordbiom

Our employees are able to develop their careers in exciting new medical technologies, and so can you.


We are currently recruiting for a Scientist IV.  The Computer-Aided Biology (CAB) Group is part of the Platform Research Department. CAB’s focus is to introduce automation and advanced analytics to drive digital transformation into computer-aided design to accelerate and optimise laboratory workflows.


Your responsibilities in this role would be:


  • To assist in the development and implementation of new and existing analytical methods and techniques as required by the platform.
  • To execute pre-validation, qualification and validation studies for internal and client work
  • To liaise with analytical departments (GMP and Research) in order to facilitate the execution of high-throughput automated protocols
  • To perform data analysis using complex Excel spreadsheets
  • To write, revise SOPs and provide training
  • Accountable for own performance in alignment with group objectives and deadlines.
  • Ensure a high standard of record keeping and documentation of experiments and investigations in order that information is clearly captured, disseminated and reported.
  • Present scientific data at internal meetings
  • Will report to the Group Leader or his/her delegated grade 5 or Principal Scientist.
  • Conduct research and technical support of the highest quality, largely in a single project area but will assist in other projects as the need arises.
  • Responsible for maintenance of a laboratory area and/or important equipment.
  • Preparation of reports and documents to support GxP and regulatory activities.


To be successful in this role, you will have the following skills and experience:


Essential Requirements:


  • Minimum BSc Degree programme level with relevant experience
  • A deep understanding and practical experience of AAV vectorology
  • A wider understanding of the AAV life cycle and aspects of virology in general
  • Demonstrable success in general molecular and cellular biology (tissue culture) techniques
  • Preferably an understanding of AAV vector quality attributes and analytics
  • Preferably an understanding of the challenges in viral vector manufacturing and scale-up
  • An understanding, and preferably first-hand experience, in risk-assessing GMs
  • Good research and development background in protein and molecular biology techniques (nucleic acid extraction, quantitative real-time PCR, ddPCR, ELISA)
  • Experience in flow cytometry
  • A strong background in assay development
  • Competency in performing laboratory tasks and general experimental procedures with expertise in one or more areas.
  • Understanding of laboratory health and safety requirements.
  • Competency in data capture reporting and management systems e.g. PatentSafe and archiving
  • Experience with digitally enable robotics and automation
  • Experience of automated data analysis and/or visualization software e.g. JMP


Desirable Requirements:


  • Some knowledge of different coding languages
  • Experience in working in GMP-like environments


Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.


Collaborate. Contribute. Change lives


No agencies please