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Scientist II/III/IV PRD (Downstream)

Date: 13-Mar-2023

Location: Oxford, GB

Company: oxfordbiom

We want you to feel inspired every day. We’re future-focused and our business is growing. We succeed together through passion, commitment, and teamwork, and so can you. 


We are currently recruiting for multiple Scientist roles within Downstream Process Development to join the team.  The purpose of this role is to perform and report laboratory-based experiments or investigations in accordance with scientific or regulatory requirements in line with departmental objectives.


Process Research & Development (PR&D) is responsible for the development of world-class viral vector manufacturing processes for Oxford Biomedica’s proprietary products and partnered programmes. PR&D performs a crucial technical role in Oxford Biomedica’s mission to deliver life-changing gene therapies to patients. 



Your responsibilities in this role would be:


  • Involvement in activities ranging from vector production at laboratory and pilot scales, process development and optimisation, technology transfer, and process characterization activities associated with the manufacture of new gene therapy vectors.
  • Design and execute downstream vector purification and vector formulation activities for scale-up/scale-down of existing bioprocesses under the direction of the Team Leader or a senior scientist and in accordance with correct methodologies and procedures.
  • Prepare written reports to a high standard and present data within the Process R&D group.
  • Liaise with other members of the Process R&D group and assist with other development activities where appropriate.
  • Ensure a high standard of record keeping and documentation of experiments and investigations.
  • Writing of departmental risk assessments, SOPs, and other documentation where appropriate.



We are looking for: 


  • Minimum BSc Degree programme level, a postgraduate degree and/or relevant experience
  • Sound understanding of downstream purification principles and processes.
  • Pharmaceutical industry experience in biological research and development or equivalent experience gained elsewhere.
  • Experience with the operation of laboratory, pilot or production scale downstream purification processes.
  • Competency in data capture, reporting and management systems.
  • The capability of explaining clearly why an experiment is being conducted and how the experiments help the group meet their objectives.
  • Awareness of regulatory requirements e.g. GMP, GLP, GCP and/or Validation and Quality Management systems.
  • Familiarity with data analysis software packages such as Microsoft Excel, JMP, Design Expert™, GraphPad Prism
  • Fluency in written and spoken English.



About Us: 


We are an innovative leading viral vector specialist focused on delivering life changing therapies to patients. 

Our innovative solutions and proven expertise allow us and our customers, the biotech and biopharma industry, to deliver life-saving therapies to reach even more patients. 

The success of cell and gene therapy products transforms outcomes for millions of people suffering from some of the world’s worst diseases and medical conditions. 


We work together, motivated to make a difference, and so can you.  



What’s in it for you: 


  • Highly competitive reward packages 
  • Wellbeing programmes 
  • Development opportunities 
  • A 35-hour working week 
  • Welcoming, friendly, supportive colleagues 
  • A diverse and inclusive working environment 
  • Our values are: Deliver Innovation, Be Inspiring and Have Integrity 
  • State of the art laboratory and manufacturing facilities