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Scientist III, Process Research & Development (Upstream)

Date: 02-Mar-2023

Location: Oxford, GB

Company: oxfordbiom

Do want you to feel inspired every day? We’re a future-focused business that is growing through the passion and commitment of our teamwork. Together we can succeed, and so can you. 


We are currently recruiting for a Scientist lll PRD (Upstream) to join the team.  The purpose of this role is to perform and report laboratory-based experiments or investigations, in accordance with scientific or regulatory requirements, and in line with departmental objectives.


Oxford Biomedica’s Process R&D team consists of experienced scientists and engineers that have extensive expertise in all aspects of upstream and downstream development.  PR&D take processes from the laboratory “bench” scale and apply process expertise and engineering fundamentals for delivery to Manufacturing.



Your responsibilities in this role would be:

  • Perform routine suspension cell culture activities to support viral vector production within the Process R&D group.
  • Develop and optimize platform upstream cell culture processes for producing lentiviral vectors, working within small project teams in the Process R&D group.
  • Design and execute small scale and laboratory scale bioreactor cell culture activities for scale-up/scale-down of existing bioprocesses.
  • Support new product process development and scale-up activities for viral vector production in GMP.
  • Involvement in activities ranging from viral vector production, process optimization, technology transfer, and process validation activities associated with the manufacture of new gene therapy vectors.
  • Lead the execution of experiments /investigations in accordance with correct methodologies and procedures, under the direction of a Team Leader or senior scientist.


We are looking for: 


  • Minimum BSc Degree programme level.
  • Postgraduate degree and/or relevant experience working with viral vectors is desirable.
  • A sound understanding and/or experience of basic mammalian suspension cell culture principles and processes.
  • Experience with the operation of laboratory, pilot or production scale cell culture bioreactors is desired.
  • Pharmaceutical industry experience in biological research and development, or equivalent experience gained elsewhere.
  • Someone who is innovative, shows initiative, and is collaborative.
  • Demonstrates good time management skills to be able to effectively manage their own workload.
  • Fluency in written and spoken English, with good presentation skills.



About Us: 


We are an innovative, leading viral vector specialist focused on delivering life changing therapies to patients. Our innovative solutions, and proven expertise, allow our customers, the biotech and biopharma industry, to deliver life-saving therapies to patients. 

The success of cell and gene therapy products can transform outcomes for millions of people suffering with some of the world’s worst diseases and medical conditions. 


By working together, we are motivated to make a difference.


 What’s in it for you: 


  • Highly competitive reward packages 
  • Wellbeing programmes 
  • Development opportunities 
  • A 35-hour working week 
  • Welcoming, friendly, supportive colleagues 
  • A diverse and inclusive working environment 
  • Our values are: Deliver Innovation, Be Inspiring and Have Integrity 
  • State of the art laboratory and manufacturing facilities 


We want you to feel inspired every day. We’re future-focused and our business is growing. We succeed together through passion, commitment, and teamwork, and so can you. 


Collaborate. Contribute. Change lives