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Principal Scientist, AAV - Cell Engineering

Date: 20-Nov-2021

Location: Oxford, GB

Company: oxfordbiom

Our employees are able to develop their careers in exciting new medical technologies, and so can you.


We are currently recruiting for a Principal Scientist to lead the AAV research within the Cell Engineering Group (CEG) which is a group within the Platform Research Department. The purpose of the role is to evaluate new systems and cell lines for efficient AAV production.

Your responsibilities in this role would be:

  • Responsible for evaluating AAV vector kits and alternative cell lines to establish the best systems to implement for high titre AAV production
  • Evolve to evaluate the benefit of stable cell lines for the production of AAV
  • Line manage at least one direct report ensuring correct training/development of the team members in necessary techniques and general learning
  • This role will be predominantly lab based with some office time for managing the project and direct report(s)
  • Support/input into tech-transfer of AAV vector processes and/or feasibility studie
  • Report writing,
  • Support potential client programmes and the daily management of the AAV programme within CEG


To be successful in this role, you will have the following skills and experience:


  • PhD and post-doctoral experience in a directly relevant field (i.e. AAV vectors) in either academia or industry
  • A deep understanding and practical experience of AAV production and AAV vector quality attributes and analytics
  • Demonstrable success in general molecular and cellular biology (tissue culture) techniques
  • Experience with the generation of stable cell lines
  • Preferably an understanding of the challenges in viral vector manufacturing and scale-up
  • Preferably an understanding of the generation of AAV stable cell lines
  • An understanding, and preferably first-hand experience, in risk-assessing GMs


Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.


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