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Group Lead - Mass Spectrometry

Date: 23-Sep-2022

Location: Oxford, GB

Company: oxfordbiom

We are at the centre of the rapidly growing cell and gene therapy sector. We deliver life-changing therapies to patients, and so can you. 


We are currently recruiting for a Group Lead - Mass Spectrometry to join the Platform Research Group. The purpose of this role is manage the performance of the group and major projects with a tactical focus on meeting the scientific, technical, and regulatory requirements of the department in line with company goals.


PPG (Platform Proteomics Group) is responsible for the development of research-level technologies and aid in the transition to Process R&D and GMP QC analytics groups. The successful candidate will work closely with the research groups working on understanding cell and viral/vector biology. 


Your responsibilities in this role would be: 

  • Group Leadership: Independent daily management of group functions, including scheduling and monitoring of individual tasks. 
  • CDMO: Interact with VP Research, Director of PRG, Analytical Development Managers to ensure all mass spectrometry experiments are accurately described in client proposals and project plans. Write and review MS components of customer reports and presentations. Present data concisely at internal meetings and/or external conferences. 
  • Data analysis: Work with Bioinformaticians to process and analyse raw MS data files. Evaluate and propose new methods of MS data analysis. 
  • Operations: Work with lab managers/technical leads and take care of infrastructure management, including daily maintenance, operation and troubleshooting of MS and automation platform, preventative maintenance of MS and associated equipment, support negotiation of annual service contracts, supply of key consumables and spares. Provide management with technology recommendations. 
  • GMP Analytics: Lead the strategy for implementation of LC-MS-based analytics into GMP. Conduct investigative, pre-validation, validation and qualification projects for assay implementation into GMP. 
  • Innovation: Evaluate new analytical methods and technologies. Perform LC-MS based label free quantitative proteome and absolute quantitation internal/client products. MS absolute quant using specific software. 
  • Ensure a high standard of record keeping and documentation of experiments and investigations in order that information is clearly captured and disseminated and reported. 
  • Contribute to research-related activities in OXB and provide LC-MS based analytics support to other department under request. 
  • Carry on research-related administration (risk assessment, change control, operating procedures). 


We are looking for: 


  • PhD level in a relevant subject  
  • Significant experience in protein mass spectrometry in the pharmaceutical industry  
  • Strong supervisory experience 
  • CDMO experience. Experience with communicating and interacting with third parties, clients, and collaborators. 
  • Strong understanding about QC for pharmaceutical products and experience working in GMP environment. 
  • Strong background in chemistry/protein chemistry or chemical biological sciences with a strong interest in applying mass spectrometry. 
  • Experience in proteomics using liquid chromatograph-mass spectrometry. 
  • Hands-on expertise on operating, troubleshooting LC-MS. 
  • In-depth up-to-date knowledge of LC-MS based analytics and methodologies. 
  • Good knowledge/experience of LV analytical instrumentation and qualification procedures. 


About Us: 


We are an innovative leading viral vector specialist focused on delivering life changing therapies to patients. 

Our innovative solutions and proven expertise allow us and our customers, the biotech and biopharma industry, to deliver life-saving therapies to reach even more patients. 

The success of cell and gene therapy products transforms outcomes for millions of people suffering from some of the world’s worst diseases and medical conditions. 


We work together, motivated to make a difference, and so can you.  


What’s in it for you: 


  • Highly competitive reward packages 
  • Wellbeing programmes 
  • Development opportunities 
  • A 35-hour working week 
  • Welcoming, friendly, supportive colleagues 
  • A diverse and inclusive working environment 
  • Our values are: Deliver Innovation, Be Inspiring and Have Integrity 
  • State of the art laboratory and manufacturing facilities 


We want you to feel inspired every day. We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and teamwork, and so can you. 


Collaborate. Contribute. Change lives. 


No agencies please.