Site Head, US Operations, Durham, NC.

Join Us In Changing Lives

At OXB, our people are at the heart of everything we do. We’re on a mission to enable life-changing therapies to reach patients around the world—and we’re looking for passionate individuals who embody our core values every day: Responsible, Responsive, Resilient, and Respectful.

Following the expansion of our US footprint we are recruiting for a Site Head to lead our new commercial scale viral vector facility in Durham, NC, a critical part of our global biopharmaceutical manufacturing network. 

Reporting to the Chief Operating Officer based in Europe, this role holds single-point accountability for site operations. The successful candidate will lead a cross-functional Site Leadership Team (SLT) overseeing Manufacturing, MSAT, Quality, Site Services, and Supply Chain. They will also work closely with our sites in Bedford, Massachusetts, the UK, and France to ensure OXB remains a global leader in Viral Vector CDMO capabilities.

Your responsibilities in this role would be:

• Provide strategic direction and leadership for all operations at the Durham site, ensuring the manufacture and on-time delivery of clinical and commercial products in full compliance with cGMP, internal, and client quality standards.
• Develop and implement short-, mid-, and long-term plans to drive site growth and sustainability, including engineering, safety, and capacity planning.
• Ensure site operations achieve or exceed financial objectives by delivering cost-effective, compliant, and high-quality results.
• Collaborate with senior leadership and global teams to align on strategic priorities and deliver manufacturing objectives.
• Partner with Business Development to support client engagement, strengthen customer relationships, and identify new opportunities for growth.
• Work closely with Technical Operations to ensure seamless technology transfer, process development, and execution of client manufacturing projects.
• Lead continuous improvement initiatives that enhance operational efficiency, quality, and cost-effectiveness, fostering a culture of innovation and best practices.
• Partner with Quality leadership to maintain the highest standards of compliance and performance excellence across all operations.
• Lead, develop, and motivate teams to achieve excellence in quality, compliance, productivity, safety, and talent development through clear communication and effective leadership.

We are looking for:

• Bachelor’s degree in Engineering, Life Sciences, Business Administration, or related field. Master’s or MBA preferred.
• Minimum 15 years of experience in CDMO or biopharmaceutical manufacturing operations, including 10+ years in senior leadership roles with direct responsibility for large-scale teams.
• Proven track record of leading complex, multi-functional operations in a cGMP-regulated environment.
• Deep understanding of FDA, EMA, and global regulatory standards and process performance                                                                                                                                
• Demonstrated ability to lead through influence, fostering collaboration and driving accountability across diverse teams.
• Strong financial and business acumen with experience managing P&L and capital investments.
• Excellent communication, strategic planning, and decision-making skills.
• Ability to lead through organizational change, balancing operational rigor with a forward-looking vision.
• Demonstrated success in building high-performing teams, developing talent, and driving a strong culture of engagement and inclusion.
• Ability to travel.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the United States.

About Us:

OXB is a quality and innovation-led viral vector CDMO with a mission to enable its clients to deliver life changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, we have more than 30 years of experience in viral vectors; the driving force behind the majority of gene therapies.

OXB collaborates with some of the world’s most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. OXB’s world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods, and depth of regulatory expertise.

Why Join Us?

• 💸 Competitive total reward packages
• 🧘 Wellbeing programs that support your mental and physical health
• 🚀 Career development opportunities to help you grow and thrive
• 🤝 Supportive, inclusive, and collaborative culture
• 🧪 State-of-the-art labs and manufacturing facilities
• 🌍 A company that lives its values: Responsible, Responsive, Resilient, Respect

We want you to feel inspired every day. At OXB, we’re future-focused and growing fast. We succeed together—through passion, commitment, and teamwork. 

Ready to Make a Difference?