Director, Downstream Process Development, US

Join Us in Changing Lives 

At OXB, our people are at the heart of everything we do. We’re on a mission to enable life-changing therapies to reach patients around the world—and we’re looking for passionate individuals who embody our core values every day: Responsible, Responsive, Resilient, and Respectful. 

We are currently recruiting for an Associate/Director, to join and lead the Downstream Process Development team OXB located at our Bedford, MA facility.  This role plays critical part in developing, optimizing, and scaling downstream processes, guiding the team in delivering robust and efficient process development solutions to our clients, playing a key part in advancing our mission and making a real difference. 

Your responsibilities in this role would be:

• Lead a team of Research Associates and Scientists in AAV downstream process development. Mentor, coach, and provide career development opportunities aligned with individual team members and company goals. 
• Establish and implement strategies to enhance and continuously improve OXB’s Downstream Process Development platform, ensuring delivery of efficient, scalable, and high-quality processes and products to clients.
• Partner closely with Upstream Process Development, Drug Product Development, Analytical Development, and other cross-functional teams to align on shared goals and priorities, optimizing the end-to-end development process while delivering on the pipeline. Provide technical support to cGMP manufacturing as needed.
• Serve as a key point of contact for clients, presenting technical data and updates to cross-functional stakeholders, both internally and externally. Cultivate strong relationships with client teams to support the success of their programs. 
• Leverage expertise in Chemistry, Manufacturing, and Controls (CMC) to drive the development, scale-up, and tech transfer of AAV downstream processes. Ensure all processes meet quality and regulatory standards to support clinical and commercial production. 

We are looking for:

• BS (10+), MS (8+), or PhD (6+) years industry experience. Degree in microbiology, biochemistry, biotechnology, chemical engineering, or molecular biology.
• Hands-on experience in viral vector process development, scale-up, tech transfer, and manufacturing support. Experience in unit operations including clarification, capture and polishing chromatography, and UF/DF.
• Experience with downstream process development and characterization following QbD principles.
• The ability to create strategy, implement, lead and manage a team of scientists and research associates to work in a fast-paced, highly collaborative environment.
• Strong communication and presentation skills, with the ability to effectively convey technical information to cross-functional teams and external stakeholders.
• Proven experience within a customer centric environment.

About Us:

OXB is a quality and innovation-led viral vector CDMO (Contract Development and Manufacturing Organization) with a mission to enable its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, we have more than 25 years of experience in viral vectors; the driving force behind the majority of gene therapies.

OXB collaborates with some of the world’s most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus, and adenoviral vectors. Oxford Biomedica’s world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods, and depth of regulatory expertise.

The salary range for this position: $175k - $205k per year. 

This offer range represents the anticipated base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for performance-based bonuses. Benefits offered by OXB include health insurance, 401k contributions, paid time off (PTO) and tuition reimbursement.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the United States. 

About Us: 

OXB is a quality and innovation-led viral vector CDMO with a mission to enable its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, we have more than 30 years of experience in viral vectors; the driving force behind the majority of gene therapies. 

OXB collaborates with some of the world’s most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. OXB’s world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods, and depth of regulatory expertise. 

Why Join Us?  

• 💸 Competitive total reward packages  
• 🧘 Wellbeing programs that support your mental and physical health  
• 🚀 Career development opportunities to help you grow and thrive  
• 🤝 Supportive, inclusive, and collaborative culture  
• 🧪 State-of-the-art labs and manufacturing facilities  
• 🌍 A company that lives its values: Responsible, Responsive, Resilient, Respect  

We want you to feel inspired every day. At OXB, we’re future-focused and growing fast. We succeed together—through passion, commitment, and teamwork.  

Ready to Make a Difference?