The scientific area that will be explored by the ABViP-CTP have been strategically selected to align with BBSRC initiatives and to address the challenges associated with the development and application of viral vectors in health care. These include:
- Establishment of suspension adapted packaging / producer cell lines to deliver higher efficiency production – LV, as well as other viral vectors for gene therapies and vaccines, for example, adenovirus (AV) and (AAV)
- Generation of biological insights resulting in improved viral vector targeting, tropism and/or tissue specificity.
- Improved viral vector design for gene therapy and vaccine applications
- Understanding the immunological response to viral vectors
- Viral vector delivery system optimisation and design
- Improved understanding and optimisation of bioprocessing
- Enhanced bio analytics and improved assays for viral vector characterisation
- Application of digitalisation, AI, and machine learning approaches to improve biological understanding and/or enhance productivity
- Application of fundamental bioscience to improve scale-up and production
- Understanding and/or enhancing molecular pathways for vector production and/or assembly